Brief Communication Key Role of the Postsynaptic Density Scaffold Proteins Shank and Homer in the Functional Architecture of Ca Homeostasis at Dendritic Spines in Hippocampal Neurons
نویسندگان
چکیده
Carlo Sala,1 Gautier Roussignol,2 Jacopo Meldolesi,3 and Laurent Fagni2 1Cellular and Molecular Pharmacology Section, Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Pharmacology, University of Milan, 20129 Milan, Italy, 2Institut de Génomique Fonctionelle, Unité Mixte de Recherche 5203, 34094 Montpellier, France, and 3Department of Neuroscience, Vita-Salute San Raffaele University, and Center of Excellence in the Physiopathology of Cell Differentiation, 20132 Milan, Italy
منابع مشابه
Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
The Shank family of proteins interacts with NMDA receptor and metabotropic glutamate receptor complexes in the postsynaptic density (PSD). Targeted to the PSD by a PDZ-dependent mechanism, Shank promotes the maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites. Shank and Homer cooperate to induce accumulation of IP3 receptors i...
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